We are your home away from home so let us take care of you. "Hotel the Best of Lee County" award-winning hotel invites you to visit and spend the night. We are conveniently located off Hwy 421 and close to many restaurants.Visitors to Sanford can enjoy exceptional hospitality and amenities when they choose the Holiday Inn Express Hotel & Suites. The hotel's experienced staff makes each guest feel at home. We offer extraordinary amenities to our guests, from the area's only year-round indoor pool to the evening welcome reception on Wednesdays. We have what you want. With free, hot breakfast,a well-equipped fitness center and rooms that are an oasis of comfort we continue to be the preferred choice of smart guests. Join us!