Wineries, Spas and Nights Out: A Winston-Salem Girls’ TripWinston-Salem is known as the City of Arts and Innovation, and it’s quite the destination for getawaysGoing out of town for a few days with your girlfriends offers a chance to reconnect with the busy women in your life – including yourself. Escape to Winston-Salem, and you’ll return feeling rejuvenated in mind, body and spirit thanks to much-deserved glasses of wine, amazing meals, a little pampering and a lot of laughs.Recharge Just imagine: No responsibilities for three days (or longer). Now, add visions of grandeur at historic Graylyn Estate and Kimpton Cardinal Hotel. Both luxury accommodations, the Kimpton is relatively new to the scene, exuding urban flair throughout its ideal downtown location; while Graylyn’s massive, castle-like estate is a craftsman’s masterpiece where you’ll be treated as ladies of the manor by its 24-hour butlers.Kimpton HotelsThe “living room” inside the Kimpton Cardinal Hotel is a stylish hangout off the lobbyRewind In our fast-paced world, it can be hard to find time to unwind and reflect. So, what better place to dish about your lives than a relaxing winery? Start your tasting adventure at Divine Llama Vineyards – and yes, it’s on an actual llama farm. Sign up for llama treks to explore the 77-acre estate, and be sure to try the Chardonel – it’s one of the few North Carolina wineries to produce this varietal. Or venture on to Childress Vineyards, in nearby Lexington, where you can enjoy award-winning wines in its tasting room, and the Bistro offers a scenic terrace where lunch is served daily. With more than 50 wineries in Yadkin Valley wine country, surrounding Winston-Salem, you can map out your own wine trail tour. (Please drink responsibly; designate a driver.)Refuel Nothing sets the tone for a great day better than brunch, and the big menu at Mozelle’s Fresh Southern Bistro is a crowd pleaser. Southern, Mexican, Asian and classic American dishes can all be found on the menu, but save room to split an order of bourbon pecan bread pudding or flourless chocolate torte, too. For a dose of rustic elegance, check out River Birch Lodge, featuring lunch, brunch and dinner with a wide selection of paninis, burgers, and salads as well as fish, duck and steak entrées that pair well with the list of signature cocktails. Plus, back at the Kimpton hotel, The Katharine Brasserie and Bar is earning rave reviews.The Zagster bike-share program offers 50 cruiser bikes across 10 stations in Winston-SalemA trip to “The Dash” wouldn’t be complete without sampling brews at popular Foothills Brewing. This downtown brewpub frequently hosts live music and has outdoor street seating along with upscale pub grub (order the poutine burger). Add stops at Small Batch Beer Co. and Wise Man Brewing if craft beer is your thing. You and the ladies can make your away around downtown on bikes from the Zagster bike-share program.Refocus Every girls’ trip should include a dose of you time, i.e., a day at the spa. Book services at Glass Door Salon and Spa, choosing à la carte from facials, massages and body treatments. At Graylyn, take advantage of the European Touch Spa Package, which includes an overnight stay, meals and a sizable spa credit. Next, add a paddleboard yoga class to your itinerary through the top-rated Triad ECO Adventures and make a memory together you won’t soon forget. For an extra dose of beauty, visit the Old Salem Museum and Gardens or Reynolda House Museum of American Art, each with a rich history that helped lay the foundation for Winston-Salem's Southern charm.Shawndra Russell is a travel writer and novelist based in Asheville and has written for Forbes Travel Guide, BeerAdvocate and Travel + Leisure.More FROM VISITNC.COMThere’s much to see and do in North Carolina, so read on.Explore the Tastes and Adventures of Raleigh and DurhamStay at a boutique hotel, dine at top restaurants or take a food tour. Plus, explore a museum park and state park during your visit to the neighboring cities.Beer, Sports and Nightlife: A Guys' Weekend in CharlotteWhen you want to get the guys together for a weekend, Charlotte checks all the fun boxes, including craft breweries, pro sports teams and nightlife.A Tale of Two Towns’ Adventures: Boone and Blowing RockVisit the neighboring mountain towns in the High Country, where you’ll enjoy hiking and water adventures by day, and local brews with sunset views by night.