Rx Restaurant & Bar

Visit Website

Rx Restaurant & Bar


Hours & Seasons

  • Seasons - Year Round
  • Hours - Tue-Sat:5-9pm | Sunday Brunch:10am-2 pm


  • 421 Castle Street

    Wilmington,   NC   28401


Casual but refined, with a sophisticated Southern menu, this elegant dinner and Sunday brunch gem is located near downtown Wilmington. Chef and owner James Doss is committed to bringing the freshest food directly to you utilizing the choicest harvest from local farmers, fishermen and growers. The presentation is elegant -- but the flavors are the star. Housemade soups and "Sweet Prescriptions" desserts complement the ever-changing Supper menu with snacks, firsts, mains and sides. A "must try" snack for omnivores is buffalo pigs ears. They even have an Seasonal Elixir menu, rotating local beer taps and an extensive wine list to complete your dining experience. Sunday brunch is not to be missed with DIY mimosas -- a tableside bottle of bubbly and carafe of fresh-squeezed orange juice -- and a multitude of distinctive dining choices.

How to Find Us

Explore nearby listings.


421 Castle Street
Wilmington NC 28401


Latitude: 34° 13' 41.9556" / Longitude: -77° 56' 33.6588"

Special Directions:

Located in the historic Hall's Drug Store on the corner of Fifth Ave South and Castle Street

Get directions to this location...

Request your Travel Guide

Download or order FREE guides and maps

Discover Project Project 543

Explore unique spots across North Carolina